Tolerance and Cross Tolerance in Tick Bite Sepsis
Chronic Lyme, aka; Post-Sepsis Syndrome is not about autoimmunity or inflammation as many have been led to believe. It's polar opposite, immunosuppression producing no to little antibodies resulting in tolerance to cross-tolerance from fungal antigens via tick-bite or vaccine (LYMErix). You may hear it referred to as post-sepsis, endotoxin tolerance, immunosenescence, immunoparalysis, acquired or adaptive immune deficiency. Its all the same, just a different term. It's a non-HIV B-cell AIDS illness where all the opportunistics and secondary infections are what's wrecking havoc from Epstein-barr, Coxsackie, Herpesviruses, Cytomegalovirus, Candida, Streptococcus (PANDAS), Zoster, Mycoplasma, etc. It inhibits apoptosis, destroying b-cell germinal centers, humoral (in the body or blood stream) immunosuppression but chronic inflammation in the brain.
This is why antibiotics cannot cure Lyme and why some people do feel better while on antibiotics, they are treating the secondary infections. It's also why majority then relapse as they come off antibiotics or shortly after. It's the nature of Post-Sepsis Syndrome. A trashed and mutated immune system. The definition of post-sepsis syndrome is endotoxin tolerance and cross tolerance with reactivated infections of all kinds. Tolerance means the inability to detect or fight this pathogen/toll-like receptor. Cross tolerance is the inability to detect or fight other toll-like receptors or pathogens. The immune system is permanently tolerized. People with the MS and Lupus outcomes of Lyme have an autoimmune or HLA-linked response to the secondary opportunistics of sepsis such as EBV, HHV-6, CMV.
Borrelia spirochetes shed OspA
⬇OspA is Pam3cys, a TLR2 agonist ⬇
– OspA causes tolerance, turns off the immune response and detection to TLR7/9 agonists like Herpesviruses, Epstein-Barr and all other viral infections.
Andrei Medvedev – OspA causes tolerance to TLR4 agonists, lipopolysaccharides, known as the more typical bacteria.
"Development of endotoxin tolerance following the initial “cytokine storm” phase of sepsis is thought to protect the host from an overexuberant immune response and tissue damage but at the same time, may render the host immunocompromised and more susceptible to secondary infection [18,–20].....Notably, IRAK4 kinase activity was found to be a prerequisite for conferring inhibition of LPS-inducible JNK and p38 MAPK activation following prior exposure to Pam3Cys. These results represent the first systematic analyses of the role of IRAK4 kinase activity in TLR homo- and heterotolerance and pave the way for improved understanding of how IRAK4 kinase dysregulation may underlie immunocompromised states in late sepsis.” https://www.ncbi.nlm.nih.gov/pubmed/23695305
OspA induces tolerance to TLR5 agonists or flagellins
Borrelia is the perfect stealth pathogen. The CDC/ALDF made it undetectable in 1994 to 85% of the population who have a septic shock result to TLR2 agonists by changing the testing to a high antibody concentration. Remember, it's opposite of autoimmunity or inflammation. It's global immunosuppression that produces no to little antibodies, Autoimmunity would produce high antibodies.
Gary Wormser reports that what the CDC calls "post-Lyme syndrome" is really post-sepsis with no inflammation and no autoimmunity
The CDC/ALDF/YALE criminal cabal committed research fraud to make the sickest patients on the planet undectable to pass off a fake LYMErix vaccine, that was giving victims the same stealth no antibody Post-Sepsis illness it was "intended" to prevent, all to create a monopoly off vaccines and future tick borne disease test kits. Then the same crooks turn around and trash their victims. Millions infected but not detected. Sounds like the perfect bioweapon, ya think?! Not to mention the undetected immunosuppressed children receiving vaccines resulting in them getting brain damaging viruses, or, a fungal contaminated vaccine leading to the same outcome.